The Pediatric Surgery Research Collaborative (PedSRC) is a cooperative group of pediatric surgeons and researchers committed to performing high quality clinical research in pediatric surgery. Our primary goals are to increase the quality of research protocols prior to implementation; increase the number of multicenter studies, and hence, the generalizability of study findings; and leverage resources that already exist at participating institutions. Our overarching aim is to improve care of surgical diseases in children by generating new medical knowledge.